Science

Publications & Abstracts

Sickle Cell Disease

British Journal of Haematology

  • GBT440 Increases Haemoglobin Oxygen Affinity, Reduces Sickling and Prolongs RBC Half-life in a Murine Model of Sickle Cell Disease

DOI: 10.1111/bjh.14214: http://onlinelibrary.wiley.com/doi/10.1111/bjh.14214/abstract

European Medical Journal

  • GBT440, A Novel Sickle Haemoglobin Polymerisation Inhibitor, Increases Haemoglobin Oxygen Affinity And Results In A Rapid Improvement In Haemolysis And Anaemia

Abstract Review: http://viewer.zmags.com/publication/596c0327#/596c0327/69

European Hematology Association's (EHA) 21st Congress

  • Poster Presentation

    Abstract# P371
    GBT440, a Novel HbS Polymerization Inhibitor, Increases Hb Oxygen Affinity and Results in a Rapid Improvement in Hemolysis and Anemia

  • Poster Presentation

    Abstract# P370
    Pharmacokinetics (PK) and Pharmacodynamics (PD) of GBT440, a Novel Hemoglobin S (HbS) Polymerization Inhibitor for the Treatment of Sickle Cell Disease (SCD), in Healthy Volunteers and SCD Patients

10th Sickle Cell Disease Research and Educational Symposium 2016:

  • Poster Presentation

    GBT440, a novel HbS polymerization inhibitor, increases Hb oxygen affinity and results in a rapid improvement in hemolysis and anemia.

57th American Society of Hematology (ASH) Annual Meeting:

  • Oral Presentation
    Abstract #542
    GBT440, a Potent Anti-Sickling Hemoglobin Modifier Reduces Hemolysis, Improves Anemia and Nearly Eliminates Sickle Cells in Peripheral Blood of Patients with Sickle Cell Disease
  • Poster Presentation
    Abstract #2172
    GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

56th American Society of Hematology (ASH) Annual Meeting:

  • Oral Presentation
    Abstract #217
    GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Prevents RBC Sickling in Whole Blood and Prolongs RBC Half-Life in Vivo in a Murine Model of Sickle Cell Disease
  • Poster Presentation
    Abstract #1370
    GTx011, an Anti-Sickling Compound, Improves SS Blood Rheology By Reduction of HbS polymerization Via Allosteric Modulation of O2 Affinity

55th American Society of Hematology (ASH) Annual Meeting:

  • Oral Presentation
    Abstract #316
    GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Delays Polymerization and Prevents Sickling
  • Poster Presentation
    Abstract #2207
    GTx011, a Novel Agent that Improves Rheological Properties of Sickle Cell Blood by Increasing Oxygen Affinity for Hemoglobin

Hypoxemic Pulmonary Disorders

American Thoracic Society (ATS) International Conference:

Pulmonary Fibrosis Foundation (PFF) Summit 2015:

  • Poster Presentation
    Effects of GBT1118, A Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, on Bleomycin-Induced Murine Model of Hypoxemia and Lung Fibrosis????

American Heart Association Scientific Sessions 2015:

  • Poster Presentation

    Abstract #T 4245
    GBT1118 (analog of GBT440), a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity Increases Tolerance to Hypoxia in Mice

Abstract: http://www.abstractsonline.com/pp8/#!/3795/presentation/41971